Mouse Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein (Active)

Este producto es parte de TNFRSF21 - TNF receptor superfamily member 21
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1118€ (100 µg)

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935106861
info@markelab.com
name
Mouse Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692006
tested applications
SDS-PAGE

Description

Mouse DR6 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse TNFRSF21 (NP_055267.1) extracellular domain (Met 1-His 349) was fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
DR6
Host
HEK293 cells
Assay Type
Activity: Active
Sequence Fragment: Met1-His349
Tag: C-terminal His tag
Origin
Mouse
Observed MW
35 kDa
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
100 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice
No
NCBI Accession
NP_055267.1
Alias
Tumor necrosis factor receptor superfamily member 21,DR6,CD358,BM-018,Death receptor 6
Background
Protein TNFRSF21
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method.

Descripción

TNF receptor superfamily member 21 (TNFRSF21), also known as death receptor 6 (DR6), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Like other TNFR members, TNFRSF21 is involved in processes that modulate immune responses, cell death, and survival pathways. This receptor is particularly involved in apoptosis, immune cell regulation, and central nervous system functions. TNFRSF21/DR6 is expressed in a range of tissues but is predominantly found in lymphoid organs, nervous system cells, and tissues associated with inflammatory processes. TNFRSF21 plays a significant role in neuroinflammation and neurodegeneration, as well as in the regulation of immune responses. It is a type I transmembrane protein that acts as a receptor for ligands like tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and amyloid precursor protein (APP)-derived peptides. Due to its involvement in cell apoptosis, particularly in neural cells, TNFRSF21 has garnered interest for its potential therapeutic applications in neurodegenerative diseases such as Alzheimer’s disease. Additionally, its function in immune cell regulation places it as a candidate target in autoimmune diseases and certain cancers.
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