Mouse Tyrosine-Protein Kinase Mer (MERTK) Protein (Active)

Product specifications

Proteins and Peptides

Tyrosine-Protein Kinase Mer (MERTK)

Insect

Activity: Active
Sequence Fragment: Glu573-Tyr867
Tag: N-terminal His tag and GST tag

Mouse

61.7 kDa

Recombinant

> 96% (SDS-PAGE)

50 µg

Liquid

SDS-PAGE

20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.

Shipped within 5-15 working days.

Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Shelf Life: 6 months.

No

Q60805

17289

MER,RP38,c-Eyk,c-mer,Tyro12,Receptor tyrosine kinase MerTK,Proto-oncogene c-Mer

Protein MERTK

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinase family, which plays a crucial role in the regulation of immune response, cell survival, migration, and phagocytosis. This gene was identified due to its homology with the avian oncogene v-Mer and is involved in the clearance of apoptotic cells and immune tolerance. The MERTK protein is primarily expressed in macrophages, dendritic cells, and retinal pigment epithelial cells. Dysregulation of MERTK has been implicated in various diseases, including cancer, autoimmune disorders, and retinal degenerative diseases.

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