Mouse Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) Protein (Active)

Product specifications

Proteins and Peptides

Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3)

E. coli

Activity: Active
Sequence Fragment: Glu2-Ala230
Tag: N-terminal His tag

Mouse

27.5 kDa

Recombinant

> 97% (SDS-PAGE)

50 µg

Lyophilized

SDS-PAGE

Prior to lyophilization: Sterile 50 mM Tris, 150 mM NaCl, 20% glycerol, pH 7.7.

Shipped within 5-15 working days.

Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.

No

Q9JKB1

UCH-L3,Ubiquitin thioesterase L3

Protein UCHL3

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

UCHL3 is a deubiquitinating enzyme involved in ubiquitin recycling and protein turnover, ensuring cellular protein quality control and homeostasis. It cleaves ubiquitin precursors and removes ubiquitin chains from target proteins, preventing their premature degradation by the proteasome. UCHL3 is ubiquitously expressed and plays roles in DNA repair, apoptosis, and embryonic development. It is particularly essential for spermatogenesis, where it regulates chromatin remodeling and germ cell differentiation. Loss of UCHL3 function is associated with impaired cellular proteostasis, genomic instability, and reproductive defects. Studies show its involvement in tumor progression, where dysregulation of UCHL3 alters protein degradation pathways, contributing to cancer cell survival. Knockout models exhibit defects in germ cell development, growth retardation, and increased sensitivity to cellular stress, underscoring its importance in ubiquitin regulation, cellular stability, and reproductive biology.

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