Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (Biotin)
377€ (200 µl)
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Name
Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx274320
Tested Applications
WB, IHC, IF/ICC
Description
Natural Cytotoxicity Triggering Receptor 1 (NCR1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Natural Cytotoxicity Triggering Receptor 1 (NCR1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Natural Cytotoxicity Triggering Receptor 1 (NCR1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Lymphocyte antigen 94 homolog,LY94,CD335,NKP46,NK-p46,NK cell-activating receptor,Natural killer cell p46-related protein |
| Background | Antibody anti-NCR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as NKp46 (Natural Killer Protein 46), is a type of activating receptor expressed predominantly on the surface of natural killer (NK) cells, a subset of lymphocytes that play an essential role in the immune system’s ability to recognize and eliminate infected or malignant cells. NCR1 is a critical component of the innate immune response, directly mediating NK cell cytotoxic activity. Unlike T and B cells that recognize specific antigens via receptors undergoing somatic recombination, NK cells use NCR1 and other natural cytotoxicity receptors to identify and kill target cells with stress-induced ligands or aberrant protein expression indicative of infection or transformation. NCR1 interacts with a wide range of ligands, including viral proteins, bacterial components, and tumor-associated antigens, making it essential for defense against pathogens and cancer cells. This receptor operates independently of major histocompatibility complex (MHC) restriction, allowing it to respond quickly and efficiently to abnormal cells in the body. NCR1 is part of the natural cytotoxicity receptor (NCR) family, which also includes NCR2 (NKp44) and NCR3 (NKp30), and works in concert with other activating receptors like NKG2D to promote NK cell-mediated cytotoxicity.
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