Neuropeptide FF Receptor 1 (NPFFR1) Antibody
442€ (200 µl)
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935106861
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name
Neuropeptide FF Receptor 1 (NPFFR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433057
tested applications
P-ELISA, WB
Description
NPFFR1 Antibody is a Goat Polyclonal antibody against NPFFR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Neuropeptide FF Receptor 1 (NPFFR1) Immunogen: abx615452 - Internal region: C-RPSGSHKEAYSERP |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 64106 |
| NCBI Accession | NP_071429.1 |
| Alias | NPFFR1,GPR147,NPFF1,NPFF1R1,OT7T022,G protein-coupled receptor 147,RFamide-related peptide receptor GnIH-R,GnIH-R/RFRP-3 |
| Background | Antibody anti-NPFFR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
NPFFR1, also known as GPR147, is a G protein-coupled receptor activated by neuropeptide FF (NPFF), a member of the RFamide peptide family. NPFFR1 is predominantly expressed in the central nervous system (CNS), particularly in regions involved in pain modulation, opioid signaling, and neuroendocrine regulation. Activation of NPFFR1 couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels, leading to the modulation of synaptic transmission and neuronal excitability. NPFFR1 plays a critical role in modulating opioid analgesia, acting as an anti-opioid receptor to counteract the effects of endogenous and exogenous opioids, including morphine tolerance and dependence. Additionally, NPFFR1 is involved in regulating stress responses, cardiovascular function, and neuroendocrine signaling. Dysregulation of NPFFR1 has been associated with chronic pain, opioid tolerance, and stress-related disorders. NPFFR1 antagonists are being investigated as potential therapies for enhancing opioid analgesia and reducing tolerance, while its broader roles in stress and cardiovascular regulation remain under exploration.
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