Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Antibody
260€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128689
tested applications
WB, IHC
Description
Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein Antibody is a Rabbit Polyclonal against Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Immunogen: abx166176 - Recombinant NOS1AP (Thr285-Val506) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75052 |
| Alias | NOS1AP,CAPON, nitric oxide synthase 1 adaptor protein, NPHS22 |
| Background | Antibody anti-NOS1AP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
NOS1AP, also known as CAPON, is an adaptor protein that binds to neuronal nitric oxide synthase (nNOS) via its PDZ-binding motif, regulating nNOS activity and nitric oxide (NO) production in neurons. It plays a critical role in neuronal development, synaptic signaling, and apoptosis by modulating NO signaling pathways. NOS1AP is highly expressed in the brain, particularly in regions responsible for cognition and memory, and it mediates downstream signaling of nNOS by interacting with proteins like Dexras1 and other cytoplasmic effectors. Dysregulation of NOS1AP is associated with neurological and psychiatric disorders such as schizophrenia, autism spectrum disorder, and ischemic brain injury due to abnormal NO signaling, which impacts neurotoxicity and synaptic plasticity. It also participates in cardiac function by influencing QT interval length and has been linked to arrhythmias and sudden cardiac death. Knockout and overexpression studies highlight its role in neuronal apoptosis, synaptic transmission, and cardiovascular regulation, making it a key regulator of NO-dependent signaling.
Related Products
Human Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) Protein
Human Carboxyl-Terminal PDZ Ligand of Neuronal Nitric Oxide Synthase Protein is a recombinant Human protein expressed in E. coli.
Ver Producto