RNA Cytosine C(5)-Methyltransferase NSUN2 (NSUN2) Antibody
312€ (60 µl)
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935106861
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name
RNA Cytosine C(5)-Methyltransferase NSUN2 (NSUN2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002471
tested applications
IF/ICC
Description
NSUN2 Antibody is a Rabbit Polyclonal antibody against NSUN2. This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RNA Cytosine C(5)-Methyltransferase NSUN2 (NSUN2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q08J23 |
| Gene ID | 54888 |
| NCBI Accession | NP_060225.4 |
| OMIM | 610916 |
| Background | Antibody anti-NSUN2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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NSUN2 antibody
RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine(m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
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