Nuclear Receptor ROR-Gamma (RORC) Antibody
442€ (200 µl)
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name
Nuclear Receptor ROR-Gamma (RORC) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431564
tested applications
P-ELISA, WB, IF/ICC, FCM
Description
RORC Antibody is a Goat Polyclonal antibody against RORC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Nuclear Receptor ROR-Gamma (RORC) Immunogen: abx616518 - Internal region, 200-212 AA: CHLEYSPERGKAE |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 6097, 19885 |
| NCBI Accession | NP_005051.2, NP_001001523.1 |
| Alias | TOR,RORG,RZRG,IMD42,NR1F, RZR-GAMMA,Nuclear receptor ROR-gamma,RAR-related orphan receptor C,Nuclear receptor subfamily 1 group F member 3 |
| Background | Antibody anti-RORC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
RAR related orphan receptor C (RORC), also known as RORγ, is a nuclear receptor that plays a crucial role in regulating immune responses, particularly in the differentiation of Th17 cells, which are a subset of helper T cells involved in autoimmune diseases RORC is essential for the regulation of inflammatory processes and the production of pro-inflammatory cytokines, making it a key player in the pathogenesis of conditions like rheumatoid arthritis, psoriasis, and multiple sclerosis RORC also influences the development of the thymus and other immune organs, playing a role in maintaining immune homeostasis It is involved in the regulation of metabolic processes and the response to oxidative stress and environmental factors Dysregulation of RORC expression is linked to autoimmune diseases, chronic inflammation, and cancer, where altered immune regulation contributes to disease progression Targeting RORC with specific inhibitors has been explored as a therapeutic strategy to manage autoimmune diseases and inflammatory conditions, highlighting its potential as a drug target in immune-related therapies
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