Paired Box 8 (PAX8) Antibody
442€ (200 µl)
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935106861
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name
Paired Box 8 (PAX8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433098
tested applications
P-ELISA, WB
Description
PAX8 Antibody is a Goat Polyclonal antibody against PAX8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Paired Box 8 (PAX8) Immunogen: abx269809 - Internal region: C-AQPGSDKRKMDD |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 7849 |
| NCBI Accession | NP_003457.1, NP_039245.1, NP_039246.1, NP_039247.1, NP_054698.1 |
| Alias | PAX-8 |
| Background | Antibody anti-PAX8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
PAX8 is a transcription factor required for the development of the thyroid gland, kidneys, and parts of the reproductive system. During embryogenesis, PAX8 regulates genes necessary for thyroid follicular cell differentiation and hormone synthesis, making it essential for thyroid gland formation and function. Mutations in PAX8 are associated with congenital hypothyroidism, thyroid dysgenesis, and impaired thyroglobulin production. PAX8 also plays a role in nephrogenesis, contributing to kidney development and epithelial cell differentiation. In cancers, PAX8 is frequently overexpressed in thyroid, ovarian, and renal cell carcinomas, where it serves as a diagnostic marker and regulator of oncogenic pathways. Knockout models show thyroid gland agenesis, defective renal development, and reproductive abnormalities, highlighting PAX8's role in tissue-specific gene regulation, organogenesis, and endocrine function.
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