Par-3 Partitioning Defective 3 Homolog (PARD3) Antibody (HRP)
169€ (20 µg)
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Name
Par-3 Partitioning Defective 3 Homolog (PARD3) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx308812
Tested Applications
ELISA
Description
PARD3 Antibody (HRP) is a Rabbit Polyclonal against PARD3 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Par-3 Partitioning Defective 3 Homolog (PARD3) Immunogen: Recombinant human Partitioning defective 3 homolog protein (1068-1356AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TEW0 |
| Gene ID | 56288 |
| NCBI Accession | NM_019619.3 |
| OMIM | 182940 |
| Alias | PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator |
| Background | Antibody anti-PARD3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PARD3 is a polarity protein essential for establishing and maintaining cell polarity during processes like epithelial tissue organization, asymmetric cell division, and neuronal development. It is a component of the Par complex, which includes PARD6 and atypical protein kinase C (aPKC), and regulates apical-basal polarity by interacting with tight junction components and cytoskeletal regulators. PARD3 is critical for tight junction formation, cell adhesion, and actin cytoskeleton organization in epithelial and endothelial cells. It is highly expressed in polarized tissues and neurons, where it regulates axon specification, neuronal migration, and synaptic organization. Dysregulation of PARD3 contributes to cancer progression, particularly in epithelial tumors, by disrupting cell polarity, adhesion, and promoting metastasis. PARD3 also plays roles in stem cell self-renewal, tissue homeostasis, and endothelial barrier function. Knockout studies reveal defects in tissue architecture, impaired cell polarization, and embryonic lethality, emphasizing its fundamental role in polarity establishment and tissue integrity.
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