Peroxisome Proliferator Activated Receptor Alpha (PPARa) Antibody
273€ (100 µl)
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935106861
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name
Peroxisome Proliferator Activated Receptor Alpha (PPARa) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx177972
tested applications
IHC
Description
Peroxisome Proliferator Activated Receptor Alpha (PPARa) Antibody is a Rabbit Polyclonal antibody against Peroxisome Proliferator Activated Receptor Alpha (PPARa).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Peroxisome Proliferator Activated Receptor Alpha (PPARa) Immunogen: abx652143 - Recombinant Peroxisome Proliferator Activated Receptor Alpha (PPARa) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PPAR,NR1C1,Hppar,PPARalpha,PPAR-alpha,Nuclear receptor subfamily 1 group C member 1 |
| Background | Antibody anti-PPARA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Peroxisome proliferator activated receptor alpha (PPARA) is a nuclear hormone receptor that plays a critical role in the regulation of lipid metabolism, inflammation, and energy homeostasis PPARA is primarily expressed in tissues involved in fatty acid metabolism, such as the liver, heart, and skeletal muscle, where it regulates the transcription of genes involved in the breakdown of fatty acids and lipids The receptor functions by binding to specific ligands, such as fatty acids and fibrates, which activate PPARA and induce the expression of genes involved in lipid catabolism, mitochondrial biogenesis, and oxidative stress response PPARA is also involved in regulating glucose metabolism and insulin sensitivity, making it a key player in metabolic diseases like diabetes and obesity Dysregulation of PPARA has been linked to various disorders, including cardiovascular diseases, metabolic syndrome, and fatty liver disease PPARA's role in regulating inflammation further highlights its therapeutic potential in conditions characterized by chronic inflammation, including atherosclerosis and neurodegenerative diseases
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