PHD Finger Protein 11 (PHF11) Antibody
442€ (200 µl)
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935106861
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name
PHD Finger Protein 11 (PHF11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433128
tested applications
P-ELISA, WB
Description
PHF11 Antibody is a Goat Polyclonal antibody against PHF11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: PHD Finger Protein 11 (PHF11) Immunogen: abx615559 - Internal region: C-KIHASQQRWQQLKE |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 51131 |
| NCBI Accession | NP_001035533.1, NP_001035534.1 |
| Alias | PHF11,BCAP,NY-REN-34,IGER,BRCA1 C-Terminus-Associated Protein,Renal Carcinoma Antigen NY-REN-34,NYREN34,IGHER,IGEL,APY |
| Background | Antibody anti-PHF11 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
PHF11 is a PHD domain-containing protein involved in transcriptional regulation and immune responses. It interacts with transcription factors and chromatin modifiers to regulate the expression of genes associated with inflammation, immune cell activation, and DNA repair. PHF11 plays a key role in enhancing transcriptional activity at specific genomic loci, particularly in B cells and T cells, where it regulates immune responses, including cytokine production and class-switch recombination. It is highly expressed in lymphoid tissues, supporting its role in adaptive immunity and lymphocyte function. Dysregulation of PHF11 is associated with autoimmune diseases, inflammatory disorders, and cancer, where altered transcriptional regulation disrupts immune balance and cell proliferation. Knockout studies demonstrate impaired immune responses, reduced antibody production, and defective lymphocyte activation, highlighting its importance in transcriptional regulation, immune system maintenance, and adaptive immunity.
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