Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) Antibody

Product specifications

Primary Antibodies

Target: Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2)
Immunogen: abx166054 - Recombinant PDCD1LG2 (Glu33-Phe236) expressed in E. coli

Rabbit

Human

Concentration: 1 mg/ml

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

WB, IHC

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9BQ51

80380

B7DC,Btdc,PDL2,CD273,PD-L2,PDCD1L2,PD-1 ligand 2,PDCD1 ligand 2,Butyrophilin B7-DC,B7-DC

Antibody anti-PDCD1LG2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

Programmed cell death 1 ligand 2 (PDCD1LG2), commonly referred to as PD-L2, is an immune regulatory protein that belongs to the B7 family of immune checkpoint ligands. PD-L2 functions as a ligand for PD-1 (Programmed Cell Death Protein 1), an inhibitory receptor on T cells, and contributes to the modulation of immune responses by promoting T cell inhibition. This ligand is highly relevant in immune tolerance, particularly in peripheral tissues where it helps prevent excessive immune reactions that could lead to tissue damage. PD-L2, together with its better-known counterpart PD-L1, plays a key role in immune escape mechanisms in cancers, where it inhibits T cell activation and proliferation, enabling tumor cells to evade immune surveillance. PD-L2 is selectively expressed on antigen-presenting cells (APCs) such as dendritic cells (DCs), macrophages, and B cells. Its expression is inducible, being upregulated under conditions of inflammation or during immune activation through signals like interleukin-4 (IL-4) and interferon-gamma (IFN-γ). This selective and inducible expression of PD-L2 suggests it has specialized roles in fine-tuning immune responses, distinguishing it from PD-L1, which is more broadly expressed across various cell types, including non-immune cells.

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Human Programmed Cell Death Protein 1 Ligand 2 (PDCD1LG2) Protein

Human Programmed Cell Death Protein 1 Ligand 2 is a recombinant Human protein expressed in E. coli.

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