Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody
234€ (5 µg)
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Name
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137680
Description
Pyruvate Dehydrogenase Complex Component X (PDHX) Antibody is a Mouse Monoclonal antibody against Pyruvate Dehydrogenase Complex Component X (PDHX).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Pyruvate Dehydrogenase Complex Component X (PDHX) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | DLDBP, E3BP, OPDX, PDX1, proX, pyruvate dehydrogenase complex component X, PDHXD |
| Background | Antibody anti-PDHX |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PDHX is a component of the pyruvate dehydrogenase complex (PDC) located in the mitochondrial matrix, where it plays a critical role in linking glycolysis to the tricarboxylic acid (TCA) cycle by catalyzing the conversion of pyruvate to acetyl-CoA. PDHX functions as the E3-binding protein, anchoring dihydrolipoamide dehydrogenase (E3) to the PDC core and facilitating the transfer of reducing equivalents between PDC subunits. It is essential for the stability and activity of the PDC, ensuring efficient energy production and metabolic homeostasis. Mutations in PDHX are associated with pyruvate dehydrogenase deficiency, a condition characterized by lactic acidosis, developmental delay, and neurological dysfunction due to impaired mitochondrial energy metabolism. PDHX is expressed ubiquitously in energy-demanding tissues such as the brain, muscle, and liver, where it supports ATP production and metabolic adaptation. Knockout studies demonstrate reduced PDC activity, metabolic imbalances, and severe defects in energy-dependent processes, underscoring its importance in cellular respiration and energy metabolism.
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