Rabbit Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) ELISA Kit
715€ (96 tests)
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name
Rabbit Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx362291
tested applications
ELISA
Description
Rabbit Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rabbit Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) |
| Reactivity | Rabbit |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 62.5 pg/ml - 4000 pg/ml |
| Sensitivity | < 38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ALOX15,LOG15 |
| Background | Elisa Kits for: ALOX15 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
ALOX15 catalyzes the oxygenation of arachidonic acid and linoleic acid to generate 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] and 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), respectively. These lipid intermediates are precursors for resolvins, protectins, and other specialized pro-resolving mediators (SPMs) involved in the resolution of inflammation. ALOX15 is highly expressed in reticulocytes, macrophages, and epithelial cells, where it plays roles in redox regulation, membrane remodeling, and anti-inflammatory responses. In macrophages, ALOX15 promotes the clearance of apoptotic cells (efferocytosis) and contributes to tissue homeostasis during inflammation resolution. Dysregulation of ALOX15 is associated with various pathological conditions, including asthma, atherosclerosis, diabetes, and neurodegenerative diseases. In cancer biology, ALOX15 has dual roles, acting as both a tumor suppressor by inhibiting proliferation and a pro-tumorigenic factor in specific contexts. Its ability to generate lipid mediators essential for resolving inflammation highlights its therapeutic potential in chronic inflammatory and metabolic disorders.
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