Rat AMP Deaminase 3 (AMPD3) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat AMP Deaminase 3 (AMPD3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501659
tested applications
ELISA
Description
Rat AMP Deaminase 3 (AMPD3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat AMP deaminase 3 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | AMP Deaminase 3 (AMPD3) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O09178 |
| Alias | AMP deaminase isoform E |
| Background | Elisa Kits for: AMPD3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
AMPD3 is an isoform of AMP deaminase predominantly expressed in erythrocytes (red blood cells), where it catalyzes the conversion of AMP to IMP to regulate ATP and nucleotide levels under energy stress. AMPD3 activity is essential for maintaining erythrocyte energy homeostasis, as it helps sustain ATP levels and prevents the depletion of adenine nucleotides during cellular stress. Mutations in the AMPD3 gene lead to erythrocyte AMP deaminase deficiency, a condition characterized by reduced IMP production and altered ATP metabolism, although most affected individuals remain asymptomatic. AMPD3 has been implicated in hemolytic anemias and other red blood cell disorders where impaired energy metabolism compromises erythrocyte survival and function. Beyond its role in erythrocyte physiology, AMPD3 contributes to systemic purine metabolism and may influence energy balance in other tissues. Its importance in regulating erythrocyte energy levels highlights its critical role in red blood cell longevity and overall cellular energy balance.
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Recombinant Human AMPD3
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AMP Deaminase 3 (AMPD3) Antibody
AMPD3 Antibody is a Rabbit Polyclonal antibody against AMPD3. This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
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