Rat Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Protein

Este producto es parte de CTLA4 - cytotoxic T-lymphocyte associated protein 4
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923€ (100 µg)

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935106861
info@markelab.com
name
Rat Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692107
tested applications
SDS-PAGE

Description

Rat CTLA-4 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat Ctla4 (NP_113862.1) (Met1-Asp161) was expressed with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
CTLA-4
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 15.2 kDa

Sequence Fragment: Met1-Asp161

Tag: C-terminal His tag

Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
100 µg
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_113862.1
Alias
Cytotoxic T-lymphocyte protein 4,CD,GSE,GRD4,ALPS5,CD152,Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4,IDDM12,CELIAC3,
Background
Protein CTLA4
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4), encoded by the CTLA4 gene on chromosome 2, is an essential immune checkpoint receptor primarily expressed on activated T cells and regulatory T cells (Tregs). CTLA-4 plays a crucial role in maintaining immune homeostasis by delivering inhibitory signals to downregulate T cell activation and proliferation. This receptor functions by binding to the ligands CD80 (B7-1) and CD86 (B7-2), which are expressed on antigen-presenting cells (APCs). By inhibiting excessive immune responses, CTLA-4 prevents autoimmunity and maintains immune tolerance to self-antigens. CTLA-4 is the first immune checkpoint to have been targeted for immunotherapy, exemplified by the development of the monoclonal antibody ipilimumab, which blocks CTLA-4 to boost anti-tumor immune responses. Given its significance in regulating immune responses, CTLA-4 is a focus of research in fields ranging from oncology to autoimmune disorders.
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