Rat GP145-TrkB/GP95-TrkB (TrkB) Protein
702€ (20 µg)
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935106861
info@markelab.com
name
Rat GP145-TrkB/GP95-TrkB (TrkB) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691001
tested applications
SDS-PAGE
Description
Rat TrkB Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the Rat NTRK2 (NP_036863) (Met1-His429) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | TrkB |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-His429 Tag: C-terminal Fc tag |
| Origin | Rat |
| Observed MW | 71.5 kDa |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 20 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_036863 |
| Alias | OBHD,TRKB,DEE58,trk-B,EIEE58,GP145-TrkB,Tropomyosin-related kinase B,TrkB tyrosine kinase,Neurotrophic tyrosine kinase receptor type 2,BDNF/NT-3 growth factors receptor |
| Background | Protein NTRK2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
Neurotrophic receptor tyrosine kinase 2 (NTRK2), often referred to as TrkB, interacts specifically with brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5). This receptor is central to processes like neuroplasticity, synaptic strength regulation, and long-term potentiation—mechanisms foundational for cognitive functions such as learning and memory. In addition to its role in brain health, NTRK2 is involved in mood regulation, and aberrations in its signaling pathways are associated with neuropsychiatric disorders, including depression, anxiety, and schizophrenia, emphasizing its role in mental health research and therapeutic interventions.
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