Rat Leukocyte Surface Antigen CD47 (CD47) Protein (Active)
1118€ (100 µg)
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935106861
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name
Rat Leukocyte Surface Antigen CD47 (CD47) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692377
tested applications
SDS-PAGE
Description
Leukocyte Surface Antigen Cd47 (CD47) protein is a recombinant Rat protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Leukocyte Surface Antigen Cd47 (CD47) |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Lys140 Tag: C-terminal His tag |
| Origin | Rat |
| Observed MW | 15.2 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P97829-1 |
| Alias | IAP,OA3,MER6,Antigenic surface determinant protein OA3,Integrin-associated protein, |
| Background | Protein CD47 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
CD47, also known as integrin-associated protein (IAP), is a widely expressed transmembrane glycoprotein that plays a critical role in immune regulation, cell signaling, and cellular adhesion. It is a member of the immunoglobulin superfamily and is involved in numerous biological processes, including immune evasion, apoptosis, angiogenesis, and cell migration. One of CD47's primary functions is to act as a "don't eat me" signal to prevent macrophage-mediated phagocytosis, which is a key component in the immune system's ability to clear dead cells and pathogens. CD47 interacts with signal regulatory protein alpha (SIRPα), a receptor primarily expressed on myeloid cells, such as macrophages and dendritic cells. The binding of CD47 to SIRPα sends an inhibitory signal to macrophages, preventing the phagocytosis of CD47-expressing cells. This interaction plays a critical role in protecting normal cells from immune clearance but can also be exploited by cancer cells to evade immune detection and destruction.
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