Rat Cytokine Receptor Common Subunit Gamma (IL2RG) Protein
1118€ (100 µg)
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935106861
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name
Rat Cytokine Receptor Common Subunit Gamma (IL2RG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692464
tested applications
SDS-PAGE
Description
Cytokine Receptor Common Subunit Gamma (IL2RG) protein is a recombinant Rat protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cytokine Receptor Common Subunit Gamma (IL2RG) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ala262 Tag: C-terminal His tag |
| Origin | Rat |
| Observed MW | 29.5 kDa |
| Expression | Recombinant |
| Purity | > 99% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q68FU6 |
| Alias | Cytokine receptor common subunit gamma,P64,CIDX,IMD4,CD132,SCIDX,IL-2RG,SCIDX1,IL-2 receptor subunit gamma,IL-2R subunit gamma |
| Background | Protein IL2RG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
The Interleukin 2 Receptor Subunit Gamma (IL2RG), also known as the common gamma chain or γc, is a crucial component of several cytokine receptor complexes, specifically those for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Each of these cytokines plays a vital role in immune cell development, activation, and homeostasis. Because IL2RG is part of multiple cytokine receptor systems, it is often referred to as a "common" subunit, essential for the signaling functionality of these cytokines. The expression of IL2RG is indispensable for immune competence, influencing processes in adaptive immunity and innate immune responses. In its absence, severe immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID), can occur, indicating its role in T cell, B cell, and natural killer (NK) cell development. IL2RG does not directly bind to cytokines but facilitates signal transduction by forming a complex with cytokine-specific receptor subunits and initiating intracellular signaling cascades. The signaling through IL2RG activates critical pathways, including JAK/STAT, MAPK, and PI3K/AKT, which are integral to immune cell differentiation, proliferation, and survival. Due to the centrality of IL2RG in immune system function, mutations in this gene have severe implications for immune cell functionality and host defense.
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