Rat Interleukin 7 Receptor (IL7R) Protein
247€ (10 µg)
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935106861
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name
Rat Interleukin 7 Receptor (IL7R) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168785
tested applications
WB, SDS-PAGE
Description
Rat IL7R Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 7 Receptor (IL7R) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Asp239 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 30.8 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | D4A3X8 |
| Alias | Interleukin-7 receptor subunit alpha,ILRA,CD127,IL7RA,CDW127,IMD104,sIL-7R,lnc-IL7R,IL7Ralpha,IL-7Ralpha,IL-7R-alpha,IL-7 receptor subunit alpha; IL-7R subunit alpha,IL-7RA |
| Background | Protein IL7R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
The interleukin-7 receptor (IL7R) is a critical component of immune system regulation, playing a major role in the development, survival, and homeostasis of T cells and, to a lesser extent, B cells. It is encoded by the IL7R gene and consists of two distinct subunits: IL-7Rα (CD127), which is unique to the IL-7 receptor, and γc (CD132), a common gamma chain shared with other cytokine receptors such as those for IL-2, IL-4, IL-9, IL-15, and IL-21. IL-7, the ligand for IL7R, is an essential cytokine that provides survival signals to developing lymphocytes and regulates their function, influencing T cell diversity, immune tolerance, and immune responsiveness. The IL7R signaling pathway has profound effects on immune system homeostasis, enabling it to counteract immune deficiencies, support immune recovery after depletion, and maintain immune memory. Dysregulation of IL7R, however, is implicated in a range of conditions, including severe combined immunodeficiency (SCID), autoimmune diseases, and certain cancers, especially T-cell acute lymphoblastic leukemia. The receptor’s pivotal role in lymphocyte biology makes it a significant target for immunological therapies and interventions.
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