Rat Parathyroid Hormone Receptor 2 (PTH2R) CLIA Kit

Este producto es parte de PTHR - Parathyroid Hormone Receptor
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845€ (96 tests)

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935106861
info@markelab.com
name
Rat Parathyroid Hormone Receptor 2 (PTH2R) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx197408
tested applications
CLIA

Description

Rat Parathyroid Hormone Receptor 2 (PTHR2) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Parathyroid Hormone Receptor 2 (PTHR2).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Parathyroid Hormone Receptor 2 (PTH2R)
Reactivity
Rat
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
15.6 pg/ml - 1000 pg/ml
Sensitivity
9.38 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard: Lyophilized
Tested Applications
CLIA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
PTH2R,PTHR2
Background
CLIA Kits PTH2R
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.  Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

PTH2R is a G protein-coupled receptor activated primarily by tuberoinfundibular peptide of 39 residues (TIP39) and, to a lesser extent, parathyroid hormone (PTH). Unlike PTH1R, PTH2R is not involved in calcium homeostasis but instead regulates neuroendocrine functions, pain signaling, and vasodilation. PTH2R is predominantly expressed in the central nervous system, including the hypothalamus and brainstem, as well as in pancreatic and cardiovascular tissues. It couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels. PTH2R modulates neuropeptide release, pain perception, and stress responses. Emerging evidence suggests its involvement in regulating hypothalamic-pituitary functions and modulating blood flow. Dysregulation of PTH2R signaling is linked to altered pain sensitivity, stress-related disorders, and neuroendocrine dysfunction. Targeting PTH2R has therapeutic potential for managing chronic pain, stress disorders, and cardiovascular regulation, highlighting its role in neuropeptide-mediated signaling.

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