Rat Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Protein (Active)
1638€ (200 µg)
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935106861
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name
Rat Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692731
tested applications
SDS-PAGE
Description
Rat ALK-1 Protein is a recombinant protein from Rat produced in HEK293 Cells. A synthetic DNA sequence encoding the rat ACVRL1 (NP_071886.1) extracellular domain (Met 1-Ala 118) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ALK-1 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Ala118 Tag: C-terminal His tag and Fc tag |
| Origin | Rat |
| Observed MW | 38.7 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 200 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_071886.1 |
| Alias | Activin receptor-like kinase 1,ALK-1,SKR3 |
| Background | Protein ACVRL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method. |
Descripción
ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.
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