Recombinant Human MICA
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Product specifications
| Category | Proteins and Peptides |
| Host | Mammalian Cells |
| Reactivity | Human |
| Assay Data | Centrifuge the vial at 10000 rpm for 30 s before opening, reconstitute in sterile distilled water to a concentration of 0.1-1 mg/ml by gently pipetting 2-3 times, don't vortex. |
| Recommended Dilution | ¥ |
| Isotype | ¥ |
| Clone ID | ¥ |
| Observed MW | 85-110 kDa |
| Expression | Glu24-Gln308 |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Size 1 | 10μg |
| Size 2 | 50μg |
| Size 3 | 500μg |
| Size 4 | 1mg |
| Form | Lyophilized powder |
| Tested Applications | Western Blot, ELISA |
| Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| Availability | 7 days |
| Storage | The lyophilized protein is stable at -20°C for up to 1 year. After reconstitution, the protein solution is stable at -20 to -80°C for 3 months or 1 week at 2 to 8°C under sterile conditions. For extended storage, it is recommended to further dilute in working aliquots, avoid repeated freeze/thaw cycle. |
| UniProt ID | AAH16929.1 |
| Alias | MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1 |
| Background | Protein MICA |
| Status | RUO |
| Note | Endotoxin: < 1 EU/µg as determined by LAL test. Tag : C-terminal hFc Tag |
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MICA antibody
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
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