Recombinant Human RGMA
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Product specifications
| Category | Proteins and Peptides |
| Host | E.Coli |
| Reactivity | Human |
| Observed MW | 30 kDa |
| Expression | Pro169-Gly422 |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Size 1 | 10μg |
| Size 2 | 50μg |
| Size 3 | 500μg |
| Size 4 | 1mg |
| Form | Liquid |
| Tested Applications | Western Blot, ELISA |
| Buffer | 0.2 μm filtered solution of 20 mM PB, 10% Trehalose, 50% Glycerol, 1 mM DTT, 0.05% Tween80, pH 7.8. |
| Availability | 7 days |
| Storage | The protein solution is stable at -80°C for 6 months after receipt, and for 3 months under sterile conditions after opening. Avoid repeated freeze/thaw cycle. |
| UniProt ID | AAI51133.1 |
| Alias | Repulsive guidance molecule A, RGM domain family member A, RGM |
| Background | Protein RGMA |
| Status | RUO |
| Note | Endotoxin: < 1 EU/µg as determined by LAL test. Tag : N-terminal His Tag |
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Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
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