Recombinant Human ST6GAL1
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Product specifications
| Category | Proteins and Peptides |
| Host | Mammalian Cells |
| Reactivity | Human |
| Observed MW | 41-60 kDa |
| Expression | Lys27-Cys406 |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Size 1 | 10μg |
| Size 2 | 50μg |
| Size 3 | 500μg |
| Size 4 | 1mg |
| Form | Liquid |
| Tested Applications | Western Blot, ELISA |
| Buffer | 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0. |
| Availability | 7 days |
| Storage | The protein solution is stable at -80°C for 6 months after receipt, and for 3 months under sterile conditions after opening. Avoid repeated freeze/thaw cycle. |
| UniProt ID | P15907 |
| Alias | Beta-Galactoside Alpha-2, 6-Sialyltransferase 1, Alpha 2,6-ST 1, B-Cell Antigen CD75, CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2, 6-Sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1, ST6GAL1, SIAT1 |
| Background | Protein ST6GAL1 |
| Status | RUO |
| Note | Endotoxin: < 1 EU/µg as determined by LAL test. Tag : C-terminal His Tag |
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This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described.
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ST6GAL1 (β-galactoside α-2-6 sialyl transferase1; also known as ST6N or CD75) is a sialyltransferase mediating the glycosylation of proteins and lipids to form functionally important glycoproteins and glycolipids in the Golgi compartment. It is principally expressed in liver, placenta and skeletal muscle. ST6GAL1 undergoes proteolytic process to generate soluble form from membrane form. Western blot analysis of human liver using this antibody detects both isoforms between 43-50 kDa. Higher molecular weight of bands around 50-70 kDa can also be observed with unknown reason.
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