Roundabout Homolog 1 (ROBO1) Antibody
442€ (200 µl)
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name
Roundabout Homolog 1 (ROBO1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430381
tested applications
P-ELISA, IHC, IF/ICC
Description
ROBO1 Antibody is a Goat Polyclonal antibody against ROBO1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Roundabout Homolog 1 (ROBO1) Immunogen: abx269818 - Internal region: C-GDVDLSNKINEMK |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC, IF/ICC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y6N7 |
| Gene ID | 6091 |
| NCBI Accession | NP_002932.1, NP_598334.1 |
| OMIM | 602430 |
| Alias | NORS,NYS8,SAX3,CPHD8,DUTT1,Deleted in U twenty twenty,H-Robo-1,Roundabout homolog 1 |
| Background | Antibody anti-ROBO1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ROBO1 (Roundabout Guidance Receptor 1) is a key transmembrane protein implicated in axon guidance during neural development, where it functions as a receptor for Slit family proteins. Through its interaction with Slit ligands, ROBO1 mediates axonal repulsion, which is critical for establishing neural circuits and ensuring proper brain organization. It is also involved in regulating cell migration, particularly in processes such as angiogenesis and tumorigenesis, by modulating cytoskeletal dynamics. Dysregulation or mutations in ROBO1 have been associated with neurological disorders and cancer progression, emphasizing its significance in both developmental and pathological contexts.
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