SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) Antibody
221€ (50 µg)
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Name
SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx328306
Tested Applications
ELISA, WB, IHC
Description
SHC1 (pY427) Antibody is a Rabbit Polyclonal against SHC1 (pY427).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SHC Adaptor Protein 1 Phospho-Tyr427 (SHC1 pY427) Immunogen: Synthesized peptide derived from human Shc around the phosphorylation site of Y427. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29353 |
| Gene ID | 6464 |
| Alias | SHC1, SHCA, SHC adaptor protein 1,SHC-transforming protein 1 |
| Background | Antibody anti-SHC1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SHC1 is an adaptor protein that plays a critical role in linking receptor tyrosine kinases (RTKs) and cytokine receptors to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and JNK. It contains PTB and SH2 domains that mediate interactions with phosphorylated tyrosine residues on activated receptors, facilitating the recruitment of Grb2 and SOS to activate Ras signaling. SHC1 is widely expressed and is involved in cellular processes such as proliferation, survival, differentiation, and stress responses. It exists in multiple isoforms, including p46, p52, and p66, with p66 SHC1 acting as a redox sensor that regulates oxidative stress and apoptosis. Dysregulation of SHC1 contributes to cancer progression, as it enhances cell survival and proliferation through oncogenic signaling pathways, and has also been linked to aging and cardiovascular diseases. Knockout studies reveal defects in growth factor signaling, increased oxidative stress resistance, and reduced tumorigenesis, underscoring its dual role in promoting survival signaling and regulating cellular stress responses.
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