Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Peptide
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Description
Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Peptide is a synthetic peptide. This peptide is used in the production of
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) |
| Host | Synthetic |
| Assay Type | Activity: Not tested. Sequence Fragment: Internal region: C-SYKSQLNYKTKQ |
| Recommended Dilution | BL (predicted): 0.5 mg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | P-ELISA |
| Buffer | Prior to lyophilization: Deionized water. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 27181 |
| NCBI Accession | NP_055257.2 |
| Alias | SAF2,SIGLEC-8,SIGLEC8L,Sialoadhesin family member 2 |
| Background | Protein SIGLEC8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in deionized water. |
Descripción
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Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2, 3-linked sialic acid. and also binds to alpha2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
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