Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104099
tested applications
WB, IHC, IF/ICC
Description
Monoclonal Antibody to Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Sialic Acid-Binding Ig-Like Lectin 9 (SIGLEC9) Immunogen: SIGLEC9 (Leu23-Leu142). |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD329,CDw329,FOAP-9,siglec-9,OBBP-LIKE |
| Background | Antibody anti-SIGLEC9 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SIGLEC9 is widely expressed on neutrophils, monocytes, and subsets of T cells. It binds preferentially to α2-3-linked sialic acids on glycoproteins and glycolipids. SIGLEC9 plays a dual role in modulating immune responses by dampening excessive inflammation through its ITIM domains and enhancing the clearance of apoptotic cells by phagocytes. This protein is critical in host-pathogen interactions, as many pathogens exploit sialic acid-binding properties to evade immune detection. SIGLEC9 is being explored as a target in inflammatory diseases and cancer due to its role in modulating immune activation and resolution.
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