Snail Family Transcriptional Repressor 1 / SNAIL (SNAI1) Antibody
312€ (60 µl)
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935106861
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name
Snail Family Transcriptional Repressor 1 / SNAIL (SNAI1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004244
tested applications
IHC, IF/ICC
Description
SNAIL Antibody is a Rabbit Polyclonal antibody against SNAIL. The Drosophila embryonic protein SNAIL is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila SNAIL protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Snail Family Transcriptional Repressor 1 / SNAIL (SNAI1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95863 |
| Gene ID | 6615 |
| NCBI Accession | NP_005976.2 |
| Background | Antibody anti-SNAI1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Involved in induction of the epithelial to mesenchymal transition(EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate(TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
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