Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Antibody

Product specifications

Primary Antibodies

Target: Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)
Immunogen: abx166540 - Recombinant Human SAT1 (Met1-Glu171) expressed in E. coli

Rabbit

Human

Concentration: 0.5 mg/ml

WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

IHC

0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P21673

DC21,KFSD,KFSDX,SAT,SSAT,SSAT-1,Diamine acetyltransferase 1

Antibody anti-SAT1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

Spermidine/Spermine N1 Acetyltransferase 1 (SAT1) is a key enzyme involved in polyamine catabolism, catalyzing the acetylation of spermidine and spermine to produce acetylated derivatives that can be further metabolized or exported from the cell SAT1 regulates cellular polyamine levels, which are critical for processes such as DNA replication, transcription, translation, and cell growth Its activity is tightly controlled to maintain polyamine homeostasis, as imbalances can lead to cell death or uncontrolled proliferation Dysregulation of SAT1 has been associated with various conditions, including cancer, where altered polyamine metabolism supports tumor growth and survival SAT1 is also implicated in neurodegenerative disorders and oxidative stress responses, as polyamine metabolism influences reactive oxygen species (ROS) production and cellular damage Additionally, mutations or overexpression of SAT1 are linked to X-linked disorders such as Snyder-Robinson syndrome, characterized by intellectual disabilities and skeletal abnormalities SAT1 plays an emerging role as a potential therapeutic target for modulating polyamine metabolism in cancer and neurological diseases

Related Products

Human Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein

Human Spermidine/Spermine N1-Acetyltransferase 1 Protein is a recombinant Human protein expressed in E. coli.

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