Switch-associated protein 70 (SWAP70) Antibody
260€ (50 µl)
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Name
Switch-associated protein 70 (SWAP70) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211483
Tested Applications
ELISA, IHC
Description
SWAP70 Antibody is a Rabbit Polyclonal against SWAP70.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Switch-associated protein 70 (SWAP70) Immunogen: Fusion protein of human SWAP70. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UH65 |
| Gene ID | 23075 |
| Alias | SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70 |
| Background | Antibody anti-SWAP70 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SWAP70 is a nuclear and cytoplasmic adaptor protein involved in actin cytoskeleton remodeling, signal transduction, and B-cell activation. It functions as a guanine nucleotide exchange factor (GEF) for Rac1, facilitating actin polymerization and cell shape changes during processes such as immune cell migration, phagocytosis, and endocytosis. SWAP70 plays a critical role in B-cell development, class switch recombination (CSR), and antigen receptor signaling, linking extracellular signals to cytoskeletal rearrangement and nuclear responses. It is expressed in hematopoietic cells, epithelial tissues, and immune cells, where it coordinates cell migration, adhesion, and immune responses. Dysregulation of SWAP70 is associated with autoimmune diseases, cancer metastasis, and inflammatory disorders due to impaired actin regulation and signaling balance. Knockout studies reveal defects in B-cell maturation, impaired immune cell migration, and reduced immune responses, highlighting its essential role in cytoskeletal remodeling, cell signaling, and adaptive immunity.
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