Switch-Associated Protein 70 (SWAP70) Antibody (FITC)
169€ (20 µg)
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Name
Switch-Associated Protein 70 (SWAP70) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx311913
Description
SWAP70 Antibody (FITC) is a Rabbit Polyclonal against SWAP70 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Switch-Associated Protein 70 (SWAP70) Immunogen: Recombinant human Switch-associated protein 70 protein (1-300AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UH65 |
| Gene ID | 23075 |
| OMIM | 604762 |
| Alias | SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70 |
| Background | Antibody anti-SWAP70 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SWAP70 is a nuclear and cytoplasmic adaptor protein involved in actin cytoskeleton remodeling, signal transduction, and B-cell activation. It functions as a guanine nucleotide exchange factor (GEF) for Rac1, facilitating actin polymerization and cell shape changes during processes such as immune cell migration, phagocytosis, and endocytosis. SWAP70 plays a critical role in B-cell development, class switch recombination (CSR), and antigen receptor signaling, linking extracellular signals to cytoskeletal rearrangement and nuclear responses. It is expressed in hematopoietic cells, epithelial tissues, and immune cells, where it coordinates cell migration, adhesion, and immune responses. Dysregulation of SWAP70 is associated with autoimmune diseases, cancer metastasis, and inflammatory disorders due to impaired actin regulation and signaling balance. Knockout studies reveal defects in B-cell maturation, impaired immune cell migration, and reduced immune responses, highlighting its essential role in cytoskeletal remodeling, cell signaling, and adaptive immunity.
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