T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody
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247€ (100 µl)
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935106861
info@markelab.com
name
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx102987
tested applications
WB
Description
Polyclonal Antibody to Cluster Of Differentiation 8a (CD8a).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Immunogen: abx065941 - Recombinant Human CD8A (Ser22-Val235) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01732 |
| Alias | CD8,p32,Leu2,IMD116,CD8alpha,MAL,T-lymphocyte differentiation antigen T8/Leu-2,T-cell surface glycoprotein CD8 alpha chain |
| Background | Antibody anti-CD8A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The CD8A gene encodes the alpha subunit of the CD8 glycoprotein, a key co-receptor expressed on the surface of cytotoxic T lymphocytes (CD8+ T cells). CD8A typically forms a heterodimer with CD8B or a homodimer (CD8αα). This protein plays a central role in T-cell activation and immune surveillance by interacting with MHC class I molecules on antigen-presenting cells. The interaction stabilizes the binding of the T-cell receptor (TCR) to antigenic peptides presented by MHC class I, facilitating signal transduction and T-cell-mediated cytotoxic responses. CD8A expression is essential for the development and maturation of CD8+ T cells in the thymus. It also participates in the immune response against viral infections, tumors, and intracellular pathogens. Mutations or dysregulation of CD8A can impair T-cell function and immune homeostasis.
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Human T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Protein
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