TNF Receptor Associated Factor 1 (TRAF1) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
TNF Receptor Associated Factor 1 (TRAF1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211800
Tested Applications
ELISA, WB, IHC
Description
TRAF1 Antibody is a Rabbit Polyclonal against TRAF1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor Associated Factor 1 (TRAF1) Immunogen: Fusion protein of human TRAF1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13077 |
| Gene ID | 7185 |
| Alias | TRAF-1,TRAF1,EBI6, MGC:10353, TNF receptor associated factor 1 |
| Background | Antibody anti-TRAF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TRAF1 is an adaptor protein in the tumor necrosis factor receptor (TNFR) superfamily signaling pathways, playing a role in regulating NF-κB and MAPK activation, apoptosis, and immune responses. TRAF1 interacts with TNFR1, TNFR2, and other members of the TNF receptor family to mediate downstream signaling, promoting survival and inflammatory responses. TRAF1 is predominantly expressed in immune cells, including T cells, B cells, and macrophages, where it modulates cytokine production and apoptosis inhibition. It forms heterodimers with TRAF2 to regulate receptor complex formation and downstream signal transduction. Dysregulation of TRAF1 contributes to autoimmune diseases, chronic inflammation, and certain cancers by altering TNF signaling and immune responses. Knockdown studies show defects in cytokine production, reduced NF-κB activation, and increased susceptibility to apoptosis, underscoring its role in balancing immune homeostasis and cell survival pathways.
Productos relacionados
TNF Receptor-Associated Factor 1 (TRAF1) Antibody
TRAF1 Antibody is a Rabbit Polyclonal antibody against TRAF1. TRAF1 is a member of the TNF receptor (TNFR) associated fa…
Ver producto
Mouse TNF Receptor Associated Factor 1 (TRAF1) Protein
Mouse TRAF1 (TRAF1) is a recombinant Mouse protein expressed in E. coli.…
Ver producto
TNF Receptor Associated Factor 1 (TRAF1) Antibody
Polyclonal Antibody to TRAF1 (TRAF1).…
Ver producto