Toll-Interacting Protein (TOLLIP) Antibody (FITC)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Toll-Interacting Protein (TOLLIP) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx315510
Description
TOLLIP Antibody (FITC) is a Rabbit Polyclonal against TOLLIP conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Toll-Interacting Protein (TOLLIP) Immunogen: Recombinant Human Toll-interacting protein (86-163AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H0E2 |
| Gene ID | 54472 |
| NCBI Accession | NP_001305441.1, NM_001318512.1, NP_001305443.1, NM_001318514.1 |
| OMIM | 606277 |
| Alias | TOLLIP, IL-1RAcPIP, toll interacting protein |
| Background | Antibody anti-TOLLIP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TOLLIP is a negative regulator of Toll-like receptor (TLR) signaling, controlling inflammatory responses by inhibiting downstream activation of NF-κB and MAPK pathways. It functions as an adaptor protein that binds to TLRs and signaling intermediates, such as IRAK1 and TRAF6, to dampen excessive cytokine production and inflammatory responses during pathogen recognition. TOLLIP also plays a role in endosomal trafficking and autophagy, regulating receptor turnover and degradation to maintain immune homeostasis. It is widely expressed in immune cells, epithelial tissues, and organs like the liver and lungs, where it prevents chronic inflammation and excessive immune activation. Dysregulation or reduced expression of TOLLIP is associated with inflammatory diseases, autoimmune disorders, and increased susceptibility to infections. Knockdown studies reveal hyperactivated TLR signaling, elevated cytokine production, and impaired immune tolerance, highlighting its role as a key regulator of TLR signaling, inflammation, and immune homeostasis.
Productos relacionados
Toll-Interacting Protein (TOLLIP) Antibody
TOLLIP Antibody is a Rabbit Polyclonal antibody against TOLLIP. This gene encodes a ubiquitin-binding protein that inter…
Ver producto
Toll-Interacting Protein (TOLLIP) Antibody
Rabbit polyclonal antibody against TOLLIP protein. Immunogen region is Internal.…
Ver producto
Toll-Interacting Protein (TOLLIP) Antibody
Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by…
Ver producto