Transforming Growth Factor Beta 3 (TGFb3) Antibody
299€ (100 µl)
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935106861
info@markelab.com
name
Transforming Growth Factor Beta 3 (TGFb3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131634
tested applications
IHC
Description
Transforming Growth Factor Beta 3 Antibody is a Rabbit Polyclonal against Transforming Growth Factor Beta 3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Transforming Growth Factor Beta 3 (TGFb3) Immunogen: abx168801 Recombinant TGFb3 (Ala298-Ser409) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Pig |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15203 |
| Alias | ARVD,ARVD1,LDS5,RNHF,TGF-beta3,Latency-associated peptide LAP,Transforming growth factor beta-3 |
| Background | Antibody anti-TGFB3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
TGFB3 is another member of the TGF-β family that is predominantly involved in embryonic development, tissue remodeling, and wound healing. TGFB3 regulates processes such as epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) deposition, and immune suppression. It is highly expressed during palatogenesis, craniofacial development, and lung morphogenesis, where it plays an essential role in cell signaling and tissue architecture. TGFB3 facilitates proper scar formation and tissue repair by modulating fibroblast activation and ECM production while reducing excessive fibrosis. In cancer, TGFB3 contributes to tumor progression by inducing EMT and promoting metastatic dissemination. Mutations or dysregulation of TGFB3 are associated with cleft palate, cardiovascular abnormalities, and fibrotic diseases. Knockout models reveal impaired wound healing, disrupted tissue morphogenesis, and craniofacial defects, highlighting TGFB3’s role in tissue development, regeneration, and fibrotic regulation.
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