14-3-3 Protein Eta (YWHAH) Antibody
377€ (100 µg)
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Name
14-3-3 Protein Eta (YWHAH) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx239576
Tested Applications
ELISA, WB, IF/ICC
Description
14-3-3 Protein Eta (YWHAH) Antibody is a Rabbit Polyclonal antibody against 14-3-3 Protein Eta (YWHAH).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 14-3-3 Protein Eta (YWHAH) Immunogen: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/5000, IF/ICC: 1/10 - 1/100, IP: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 28 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04917 |
| Alias | YWHAH, YWHA1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta |
| Background | Antibody anti-YWHAH |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
YWHAH, a member of the 14-3-3 protein family, acts as an adaptor molecule that binds phosphorylated serine/threonine residues on target proteins, regulating their stability, localization, and function. YWHAH is highly expressed in the brain, where it is involved in synaptic plasticity, neurotransmitter release, and neuronal development. It interacts with key signaling molecules in pathways such as MAPK, PI3K/Akt, and dopamine receptor signaling, influencing cellular processes like survival, growth, and stress response. Dysregulation of YWHAH is associated with neurological disorders such as schizophrenia, Parkinson’s disease, and rheumatoid arthritis, where altered signaling contributes to disease pathogenesis. Elevated levels of YWHAH have been detected in autoimmune diseases, highlighting its role as a biomarker. Knockout studies demonstrate impaired synaptic transmission, defects in neuronal signaling, and altered stress adaptation, emphasizing its importance in brain function, neurodevelopment, and immune regulation.
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