Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx107460
Description
Ubiquitin carboxyl-terminal hydrolase isozyme L1 Antibody (FITC) is a Rabbit Polyclonal antibody against Ubiquitin carboxyl-terminal hydrolase isozyme L1 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Immunogen: Recombinant human Ubiquitin carboxyl-terminal hydrolase isozyme L1 protein (1-222AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09936 |
| Gene ID | 7345 |
| OMIM | 191342 |
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Background | Antibody anti-UCHL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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