Vacuolar Protein Sorting-Associated Protein 26A (VPS26A) Peptide

Product Graph
175.5€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Vacuolar Protein Sorting-Associated Protein 26A (VPS26A) Peptide
category
Proteins and Peptides
provider
Abbexa
reference
abx269475
tested applications
P-ELISA

Description

Vacuolar Protein Sorting-Associated Protein 26A (VPS26A) Peptide is a synthetic peptide.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Vacuolar Protein Sorting-Associated Protein 26A (VPS26A)
Host
Synthetic
Recommended Dilution
BL (predicted): 0.5 mg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation
Unconjugated
Observed MW
Sequence Fragment: C-Terminus: C-SPESQASAEQPEM
Size 1
100 µg
Form
Lyophilized Reconstitute in deionized water.
Tested Applications
P-ELISA
Buffer
Prior to lyophilization: Deionized water.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
9559, 30930
NCBI Accession
NP_004887.2
Background
Protein VPS26A
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Related Products

FNab09432

VPS26A antibody

Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins(Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15247922). Required for the endosomal localization of FAM21A(indicative for the WASH complex)(PubMed:22070227). Required for the endosomal localization of TBC1D5(PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP(PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R(PubMed:16407403). Involved in recycling of ADRB2(PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins(By similarity).

Ver Producto
P4247

Recombinant Human VPS26A

Ver Producto
abx034080

Vacuolar Protein Sorting-Associated Protein 26A (VPS26A) Antibody

VPS26A is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

Ver Producto