Vasoactive Intestinal Peptide Receptor (Vipr1) Antibody
442€ (200 µl)
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935106861
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name
Vasoactive Intestinal Peptide Receptor (Vipr1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431706
tested applications
P-ELISA, WB
Description
Vipr1 Antibody is a Goat Polyclonal antibody against Vipr1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Vasoactive Intestinal Peptide Receptor (Vipr1) Immunogen: abx616632 - Internal region: C-QLFSPIHGYNISRN |
| Host | Goat |
| Reactivity | Mouse, Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 22354, 24875 |
| NCBI Accession | NP_035833.2 |
| Alias | VIPR1,Pituitary adenylate cyclase-activating polypeptide type II receptor,PACAP type II receptor,PACAP-R-2,PACAP-R2,VPAC1 |
| Background | Antibody anti-VIPR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
VIPR1 is a G protein-coupled receptor activated by vasoactive intestinal peptide (VIP), a neuropeptide involved in regulating smooth muscle relaxation, vasodilation, and neurotransmission. VIPR1 couples to Gs proteins, stimulating adenylate cyclase and increasing cAMP levels, leading to relaxation of smooth muscle cells, dilation of blood vessels, and modulation of gastrointestinal motility. VIPR1 is primarily expressed in the smooth muscle of the gastrointestinal tract, blood vessels, and the central nervous system, where it plays a role in regulating vascular tone, intestinal motility, and neurotransmitter release. VIP has a significant role in regulating inflammation and immune responses, and VIPR1 signaling is involved in modulating immune cell functions. Dysregulation of VIPR1 signaling has been implicated in inflammatory diseases, gastrointestinal disorders, and cardiovascular diseases. Agonists targeting VIPR1 are being investigated for their potential to treat diseases involving smooth muscle contraction and inflammation, such as asthma, irritable bowel syndrome (IBS), and hypertension.
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