Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
364€ (100 µg)
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935106861
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name
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012353
tested applications
ELISA, IHC
Description
Von Hippel-Lindau Disease Tumor Suppressor (VHL) Antibody is a Rabbit Polyclonal antibody for the detection of VHL.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Von Hippel-Lindau Disease Tumor Suppressor (VHL) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40337 |
| Gene ID | 7428 |
| OMIM | 144700 |
| Background | Antibody anti-VHL |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
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Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor(HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
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