14-3-3 Protein Zeta/Delta Phospho-Ser58 (YWHAZ pS58) Antibody
52€ (10 µg)
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Name
14-3-3 Protein Zeta/Delta Phospho-Ser58 (YWHAZ pS58) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012400
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
Rabbit polyclonal antibody against 14-3-3 Protein Zeta/Deltaprotein phosphorylated at Serine 58. Immunogen region is Internal. Specificity is as follows for the reactive species: H:S58, M:S58, R:S58.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 14-3-3 Protein Zeta/Delta Phospho-Ser58 (YWHAZ pS58) Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human 14-3-3 zeta around the phosphorylation site of serine 58 (R-S-SP-W-R). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 3000, IHC: 1/50 - 100, IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P63104 |
| Alias | YWHAZ, 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS |
| Background | Antibody anti-YWHAZ |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
YWHAZ, a member of the 14-3-3 protein family, is a highly conserved adaptor protein that regulates signal transduction by binding to phosphorylated serine/threonine residues on target proteins. It functions as a molecular scaffold, facilitating protein-protein interactions involved in diverse cellular processes, including cell cycle progression, apoptosis, and signal transduction. YWHAZ plays a role in regulating pathways such as PI3K/Akt, MAPK, and TGF-β, influencing cell survival, proliferation, and migration. It is abundantly expressed in the brain and immune tissues, where it is critical for neuronal development, synaptic plasticity, and stress responses. Dysregulation of YWHAZ is implicated in neurological disorders, cancer progression, and metabolic diseases due to its role in stabilizing oncogenic and signaling proteins. Knockout studies reveal defects in brain development, increased apoptosis, and impaired cell signaling, underscoring its essential role as a key regulator of cellular homeostasis and signaling pathways.
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