Acyl Coenzyme A Synthetase Medium Chain Family, Member 1 (ACSM1) Antibody
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Description
ACSM1 has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). This protein acts on acids from C (4) to C (11) and on the corresponding 3-hydroxy-and 2, 3-or 3, 4-unsaturated acids (in vitro). This protein functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Acyl Coenzyme A Synthetase Medium Chain Family, Member 1 (ACSM1) Immunogen: KLH-conjugated synthetic peptide between 21-48 amino acids from the N-terminal region of human ACSM1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 65.3 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q08AH1 |
| Alias | BUCS1,MACS1 |
| Background | Antibody anti-ACSM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ACSM1 is an enzyme that activates medium-chain fatty acids by converting them into acyl-CoA esters, a key step in their metabolism for β-oxidation and lipid biosynthesis. It is primarily expressed in the liver and kidneys, where it contributes to the catabolism of dietary medium-chain fatty acids and their incorporation into energy production pathways. ACSM1 supports metabolic flexibility by facilitating the rapid oxidation of medium-chain fatty acids during fasting or high-fat dietary conditions. It also plays a role in detoxification pathways by processing fatty acid derivatives and xenobiotics. Dysregulation of ACSM1 activity has been associated with metabolic imbalances, particularly in conditions where medium-chain fatty acid metabolism is impaired, such as certain forms of fatty acid oxidation disorders. Its specificity for medium-chain substrates highlights its role in maintaining energy homeostasis and lipid processing.
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