ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody
357.5€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038412
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ADAMTS4 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Immunogen: A peptide corresponding to the C-terminal region of human ADAMTS4 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 90 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_005099 |
| Alias | KIAA0688, Type 1 Motif 4,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ,Aggrecanase-1,ADAM-TS4,ADAMTS-4 |
| Background | Antibody anti-ADAMTS4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADAMTS4, also known as A Disintegrin And Metalloproteinase with Thrombospondin Motifs 4, is a member of the ADAMTS protein family. ADAMTS4 contains multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS4 is primarily known for its role in extracellular matrix remodeling, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. ADAMTS4 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix and contributing to the pathogenesis of osteoarthritis and other joint-related disorders. It is one of the key enzymes involved in cartilage degradation in osteoarthritis.ADAMTS4 has been implicated in various diseases, particularly osteoarthritis. Elevated levels of ADAMTS4 expression have been observed in osteoarthritic cartilage, synovial fluid, and serum, suggesting its involvement in the disease process. Inhibition of ADAMTS4 activity has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation.Research on ADAMTS4 has implications for understanding the pathogenesis of osteoarthritis and other joint-related disorders. Targeting ADAMTS4 activity or expression may represent a promising therapeutic approach for these conditions. Additionally, further research into the regulation and function of ADAMTS4 may provide insights into its roles in normal physiology and other diseases.
Productos relacionados
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody
ADAMTS4 Antibody is a Rabbit Polyclonal antibody against ADAMTS4. This gene encodes a member of the ADAMTS (a disintegri…
Ver producto ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody
Rabbit Polyclonal against the ADAMTS4 protein.…
Ver producto
Rat ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) ELISA Kit
Rat ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) ELISA Kit is an ELISA Kit for the in vitro quanti…
Ver producto