ADAMTS Like 2 (ADAMTSL2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
ADAMTS Like 2 (ADAMTSL2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx211972
tested applications
ELISA, WB
Description
ADAMTSL2 Antibody is a Rabbit Polyclonal against ADAMTSL2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAMTS Like 2 (ADAMTSL2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86TH1 |
| Gene ID | 9719 |
| Alias | KIAA0605,ADAMTSL-2 |
| Background | Antibody anti-ADAMTSL2 |
| Status | RUO |
Descripción
ADAMTSL2 is an extracellular glycoprotein known for its role in ECM organization and fibrillin microfibril regulation. Mutations in the ADAMTSL2 gene have been linked to Geleophysic dysplasia, a rare autosomal recessive disorder characterized by short stature, joint contractures, and cardiac valvular defects. ADAMTSL2 interacts with fibrillin-1 and modulates TGF-β signaling, critical for connective tissue homeostasis. Its abnormal activity or deficiency can lead to excessive TGF-β signaling, contributing to developmental abnormalities. ADAMTSL2 is widely expressed in connective tissues, including cartilage, bone, and cardiovascular structures, reflecting its importance in ECM stability and integrity.
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