Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide (ADH4) Antibody
195€ (20 µl)
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935106861
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name
Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide (ADH4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006782
tested applications
WB
Description
ADH4 Antibody is a Rabbit Polyclonal Antibody against ADH4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide (ADH4) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human ADH4. |
| Host | Rabbit |
| Reactivity | Mouse |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 40 kDa Observed MW: 45 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08319 |
| Gene ID | 127 |
| NCBI Accession | NP_000661.2 |
| Alias | ADH-2,HEL-S-4 |
| Background | Antibody anti-ADH4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ADH4 encodes a class II alcohol dehydrogenase primarily expressed in the liver, stomach, and other tissues, where it contributes to the metabolism of various alcohols, including ethanol, retinol, and hydroxysteroids. Unlike class I enzymes, ADH4 has a broader substrate specificity and plays a key role in the detoxification of longer-chain alcohols and other xenobiotics. It is also involved in retinoic acid synthesis, linking it to pathways critical for cellular differentiation and immune responses. Genetic variations in ADH4 can influence enzyme activity and alcohol metabolism rates, impacting susceptibility to alcohol-related liver diseases and cancers. Its ability to process retinol highlights its importance in visual and developmental processes. Dysregulation or polymorphisms in ADH4 have been implicated in increased oxidative stress and tissue damage, particularly in alcohol-related gastrointestinal and liver disorders.
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