CACNA1S antibody

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Description
Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting(L-type) calcium channels belong to the 'high-voltage activated'(HVA) group. They are blocked by dihydropyridines(DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA(omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA(omega-CTx-GVIA) and omega-agatoxin-IVA(omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | calcium channel, voltage-dependent, L type, alpha 1S subunit (CACNA1S) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 200-220kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13698 |
| Gene ID | 779 |
| Alias | Voltage-dependent L-type calcium channel subunit alpha-1S,Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle,Voltage-gated calcium channel subunit alpha Cav1.1,CACNA1S,CACH1,CACN1,CACNL1A3 |
| Background | Antibody anti-CACNA1S |
| Status | RUO |
| Note | Mol. Weight 200-220 kDa |
Descripción
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