CARD11 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
CARD11 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab01268
Tested Applications
ELISA, WB, IF, IHC
Description
Involved in the costimulatory signal essential for T-cell receptor(TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | caspase recruitment domain family, member 11 (CARD11) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 133 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BXL7 |
| Gene ID | 84433 |
| Alias | CARD-containing MAGUK protein 1,CARMA1,BENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL |
| Background | Antibody anti-CARD11 |
| Status | RUO |
| Note | Mol. Weight 133 kDa |
Background
CARD11, also known as CARMA1 (Caspase Recruitment Domain-Containing Membrane-Associated Protein 1), is a critical protein in the immune system, particularly in T-cell receptor (TCR) and B-cell receptor (BCR) signaling. It acts as an adaptor protein, linking upstream receptor activation to downstream signaling pathways, including the NF-κB pathway. NF-κB activation plays an essential role in the immune response, cell survival, and inflammation. CARD11 is crucial in immune cell activation, differentiation, and the production of pro-inflammatory cytokines. Mutations or dysregulation of CARD11 can result in immune system disorders, including lymphomas, and are implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). Studies of CARD11's role in immune cell signaling have made it a potential therapeutic target for regulating immune responses and treating inflammatory or autoimmune diseases.
Productos relacionados
Caspase Recruitment Domain Family Member 11 (CARD11) Antibody
CARD11 Antibody is a Rabbit Polyclonal antibody against CARD11. The protein encoded by this gene belongs to the membrane…
Ver producto
Caspase Recruitment Domain Family Member 11 (CARD11) Antibody
Rabbit polyclonal antibody against CARD11 protein. Immunogen region is N-terminal.…
Ver producto
Caspase Recruitment Domain Family Member 11 (CARD11) Antibody
Rabbit Polyclonal against the CARD11 protein.…
Ver producto